Polymorphism C3435T of the MDR1 gene in Central Americans and Spaniards
J Vicente, B Sinues, A Fanlo, P Vasquez… - Molecular biology …, 2008 - Springer
The human multidrug resistance gene (MDR1) encodes for P-glycoprotein (P-gp) which is a
transmembrane transporter protein that acts as an efflux pump for a number of lypophilic
compounds. It plays a protective role for cells against DNA damage. The wobble C3435T
polymorphism at exon 26 has been associated with different expression levels and activity.
Differences in allele frequency of the C3435T polymorphism have been demonstrated
between distinct ethnic groups. In our study we examined these polymorphisms in 433 …
transmembrane transporter protein that acts as an efflux pump for a number of lypophilic
compounds. It plays a protective role for cells against DNA damage. The wobble C3435T
polymorphism at exon 26 has been associated with different expression levels and activity.
Differences in allele frequency of the C3435T polymorphism have been demonstrated
between distinct ethnic groups. In our study we examined these polymorphisms in 433 …
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